Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties

The identification of molecules that can modulate RNA or protein function and the subsequent chemical and structural optimization to refine such molecules into drugs is a key activity in drug discovery. Here, we explored the extent to which chemical and structural differences in antisense oligonucle...

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Detalles Bibliográficos
Autores principales: Papargyri, Natalia, Pontoppidan, Malene, Andersen, Mikael R., Koch, Troels, Hagedorn, Peter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965521/
https://www.ncbi.nlm.nih.gov/pubmed/31951854
http://dx.doi.org/10.1016/j.omtn.2019.12.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965521/
https://www.ncbi.nlm.nih.gov/pubmed/31951854
http://dx.doi.org/10.1016/j.omtn.2019.12.011

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