A model for gain of function in superoxide dismutase

Studies have found that mutant, misfolded superoxide dismutase [Cu–Zn] (SOD1) can convert wild type SOD1 (wtSOD1) in a prion-like fashion, and that misfolded wtSOD1 can be propagated by release and uptake of protein aggregates. In developing a prion-like mechanism for this propagation of SOD1 misfol...

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Detalles Bibliográficos
Autores principales: Healy, Eamonn F., Roth-Rodriguez, Analise, Toledo, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965706/
https://www.ncbi.nlm.nih.gov/pubmed/31970293
http://dx.doi.org/10.1016/j.bbrep.2020.100728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965706/
https://www.ncbi.nlm.nih.gov/pubmed/31970293
http://dx.doi.org/10.1016/j.bbrep.2020.100728

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