Duration of pretomanid/moxifloxacin/pyrazinamide therapy compared with standard therapy based on time-to-extinction mathematics

OBJECTIVES: Animal models have suggested that the combination of pretomanid with pyrazinamide and moxifloxacin (PaMZ) may shorten TB therapy duration to 3–4 months. Here, we tested that in the hollow-fibre system model of TB (HFS-TB). METHODS: A series of HFS-TB experiments were performed to compare...

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Detalles Bibliográficos
Autores principales: Srivastava, Shashikant, Deshpande, Devyani, Magombedze, Gesham, van Zyl, Johanna, Cirrincione, Kayle, Martin, Katherine, Bendet, Paula, Berg, Alexander, Hanna, Debra, Romero, Klaus, Hermann, Dave, Gumbo, Tawanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966096/
https://www.ncbi.nlm.nih.gov/pubmed/31713607
http://dx.doi.org/10.1093/jac/dkz460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966096/
https://www.ncbi.nlm.nih.gov/pubmed/31713607
http://dx.doi.org/10.1093/jac/dkz460

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