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A Synthetic Tetramer of Galectin-1 and Galectin-3 Amplifies Pro-apoptotic Signaling by Integrating the Activity of Both Galectins
Galectin-1 (G1) and galectin-3 (G3) are carbohydrate-binding proteins that can signal apoptosis in T cells. We recently reported that a synthetic tetramer with two G1 and two G3 domains (“G1/G3 Zipper”) induces Jurkat T cell death more potently than G1. The pro-apoptotic signaling pathway of G1/G3 Z...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966408/ https://www.ncbi.nlm.nih.gov/pubmed/31998689 http://dx.doi.org/10.3389/fchem.2019.00898 |