A Synthetic Tetramer of Galectin-1 and Galectin-3 Amplifies Pro-apoptotic Signaling by Integrating the Activity of Both Galectins

Galectin-1 (G1) and galectin-3 (G3) are carbohydrate-binding proteins that can signal apoptosis in T cells. We recently reported that a synthetic tetramer with two G1 and two G3 domains (“G1/G3 Zipper”) induces Jurkat T cell death more potently than G1. The pro-apoptotic signaling pathway of G1/G3 Z...

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Detalles Bibliográficos
Autores principales: Farhadi, Shaheen A., Fettis, Margaret M., Liu, Renjie, Hudalla, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966408/
https://www.ncbi.nlm.nih.gov/pubmed/31998689
http://dx.doi.org/10.3389/fchem.2019.00898

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