Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the p53 Status

Polo-like kinase 1 (Plk1), a master regulator of mitotic cell division, is highly expressed in non-small cell lung cancer (NSCLC) making it an interesting drug target. We examined the in vitro therapeutic effects of volasertib, a Plk1 inhibitor, in combination with irradiation in a panel of NSCLC ce...

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Detalles Bibliográficos
Autores principales: Van den Bossche, Jolien, Domen, Andreas, Peeters, Marc, Deben, Christophe, De Pauw, Ines, Jacobs, Julie, De Bruycker, Sven, Specenier, Pol, Pauwels, Patrick, Vermorken, Jan Baptist, Lardon, Filip, Wouters, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966428/
https://www.ncbi.nlm.nih.gov/pubmed/31795121
http://dx.doi.org/10.3390/cancers11121893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966428/
https://www.ncbi.nlm.nih.gov/pubmed/31795121
http://dx.doi.org/10.3390/cancers11121893

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