FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM

FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously found that FLT3-ITD activates the mTORC1/S6K/4EBP1 pathway cooperatively through the STAT5/PIM and PI3K/AKT pathways to promote proliferation and survival by enhancing...

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Detalles Bibliográficos
Autores principales: Watanabe, Daisuke, Nogami, Ayako, Okada, Keigo, Akiyama, Hiroki, Umezawa, Yoshihiro, Miura, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966435/
https://www.ncbi.nlm.nih.gov/pubmed/31756944
http://dx.doi.org/10.3390/cancers11121827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966435/
https://www.ncbi.nlm.nih.gov/pubmed/31756944
http://dx.doi.org/10.3390/cancers11121827

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