Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin

IDH1(R132H) (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. IDH1(wt) converts isocitrate to α-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP(+)), whereas IDH1(R132H) uses α-ketoglutarate and NADPH to generate the oncomet...

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Detalles Bibliográficos
Autores principales: Biedermann, Julia, Preussler, Matthias, Conde, Marina, Peitzsch, Mirko, Richter, Susan, Wiedemuth, Ralf, Abou-El-Ardat, Khalil, Krüger, Alexander, Meinhardt, Matthias, Schackert, Gabriele, Leenders, William P., Herold-Mende, Christel, Niclou, Simone P., Bjerkvig, Rolf, Eisenhofer, Graeme, Temme, Achim, Seifert, Michael, Kunz-Schughart, Leoni A., Schröck, Evelin, Klink, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966450/
https://www.ncbi.nlm.nih.gov/pubmed/31888244
http://dx.doi.org/10.3390/cancers11122028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966450/
https://www.ncbi.nlm.nih.gov/pubmed/31888244
http://dx.doi.org/10.3390/cancers11122028

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