(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

Topoisomerase (TOP) I plays a major role in the process of supercoiled DNA relaxation, thereby facilitating DNA replication and cell cycle progression. The expression and enzymatic activity of TOP I is positively correlated with tumor progression. Although the anticancer activity of (S)-10-Hydroxyca...

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Detalles Bibliográficos
Autores principales: Song, Mengqiu, Yin, Shuying, Zhao, Ran, Liu, Kangdong, Kundu, Joydeb Kumar, Shim, Jung-Hyun, Lee, Mee-Hyun, Dong, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966462/
https://www.ncbi.nlm.nih.gov/pubmed/31817790
http://dx.doi.org/10.3390/cancers11121964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966462/
https://www.ncbi.nlm.nih.gov/pubmed/31817790
http://dx.doi.org/10.3390/cancers11121964

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