SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors-1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets

Background: SerpinB3 (SB3) is a hypoxia and hypoxia-inducible factor (HIF)-2α-dependent cysteine-protease inhibitor up-regulated in hepatocellular carcinoma (HCC), released by cancer cells and able to stimulate proliferation and epithelial-to-mesenchymal-transition. Methods: In the study we employed...

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Detalles Bibliográficos
Autores principales: Cannito, Stefania, Foglia, Beatrice, Villano, Gianmarco, Turato, Cristian, C Delgado, Teresa, Morello, Elisabetta, Pin, Fabrizio, Novo, Erica, Napione, Lucia, Quarta, Santina, Ruvoletto, Mariagrazia, Fasolato, Silvano, Zanus, Giacomo, Colombatto, Sebastiano, Lopitz-Otsoa, Fernando, Fernández-Ramos, David, Bussolino, Federico, Sutti, Salvatore, Albano, Emanuele, Martínez-Chantar, Maria Luz, Pontisso, Patrizia, Parola, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966556/
https://www.ncbi.nlm.nih.gov/pubmed/31817100
http://dx.doi.org/10.3390/cancers11121933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966556/
https://www.ncbi.nlm.nih.gov/pubmed/31817100
http://dx.doi.org/10.3390/cancers11121933

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