IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage

Aberrant expression of GLI1 is responsible for aggressive tumor behavior and survival due to its effects on the DNA damage response (DDR). We investigated whether interleukin (IL)-24, a tumor suppressor, inhibits GLI1 and the associated DDR pathway in human NSCLCs. IL-24 treatment reduces mRNA and p...

Descripción completa

Detalles Bibliográficos
Autores principales: Panneerselvam, Janani, Srivastava, Akhil, Mehta, Meghna, Chen, Allshine, Zhao, Yan D., Munshi, Anupama, Ramesh, Rajagopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966580/
https://www.ncbi.nlm.nih.gov/pubmed/31783569
http://dx.doi.org/10.3390/cancers11121879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966580/
https://www.ncbi.nlm.nih.gov/pubmed/31783569
http://dx.doi.org/10.3390/cancers11121879

Ejemplares similares