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IL-24 Inhibits Lung Cancer Growth by Suppressing GLI1 and Inducing DNA Damage
Aberrant expression of GLI1 is responsible for aggressive tumor behavior and survival due to its effects on the DNA damage response (DDR). We investigated whether interleukin (IL)-24, a tumor suppressor, inhibits GLI1 and the associated DDR pathway in human NSCLCs. IL-24 treatment reduces mRNA and p...
Autores principales: | Panneerselvam, Janani, Srivastava, Akhil, Mehta, Meghna, Chen, Allshine, Zhao, Yan D., Munshi, Anupama, Ramesh, Rajagopal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966580/ https://www.ncbi.nlm.nih.gov/pubmed/31783569 http://dx.doi.org/10.3390/cancers11121879 |
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