ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output

Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC cells, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Terzuoli, Erika, Bellan, Cristiana, Aversa, Sara, Ciccone, Valerio, Morbidelli, Lucia, Giachetti, Antonio, Donnini, Sandra, Ziche, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966589/
https://www.ncbi.nlm.nih.gov/pubmed/31817719
http://dx.doi.org/10.3390/cancers11121963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966589/
https://www.ncbi.nlm.nih.gov/pubmed/31817719
http://dx.doi.org/10.3390/cancers11121963

Ejemplares similares