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ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output

Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC cells, we...

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Detalles Bibliográficos
Autores principales:	Terzuoli, Erika, Bellan, Cristiana, Aversa, Sara, Ciccone, Valerio, Morbidelli, Lucia, Giachetti, Antonio, Donnini, Sandra, Ziche, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966589/ https://www.ncbi.nlm.nih.gov/pubmed/31817719 http://dx.doi.org/10.3390/cancers11121963

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