Cargando…

Double-Edged Lipid Nanoparticles Combining Liposome-Bound TRAIL and Encapsulated Doxorubicin Showing an Extraordinary Synergistic Pro-Apoptotic Potential

Although TRAIL (TNF-related apoptosis-inducing ligand, also known as Apo2L) was described as capable of inducing apoptosis in transformed cells while sparing normal cells, limited results obtained in clinical trials has limited its use as an anti-tumor agent. Consequently, novel TRAIL formulations w...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Miguel, Diego, Gallego-Lleyda, Ana, Martinez-Ara, Miguel, Plou, Javier, Anel, Alberto, Martinez-Lostao, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966652/ https://www.ncbi.nlm.nih.gov/pubmed/31817469 http://dx.doi.org/10.3390/cancers11121948

Ejemplares similares

Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma
por: Gallego-Lleyda, Ana, et al.
Publicado: (2018)

Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy
por: Naval, Javier, et al.
Publicado: (2019)

Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease
por: Anel, Alberto, et al.
Publicado: (2019)

Onto better TRAILs for cancer treatment
por: de Miguel, D, et al.
Publicado: (2016)

DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL
por: Marco-Brualla, Joaquín, et al.
Publicado: (2023)

Comparative effects of free doxorubicin, liposome encapsulated doxorubicin and liposome co-encapsulated alendronate and doxorubicin (PLAD) on the tumor immunologic milieu in a mouse fibrosarcoma model
por: Islam, Md. Rakibul, et al.
Publicado: (2022)

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein
por: Bosque, Alberto, et al.
Publicado: (2016)

An improved method of encapsulation of doxorubicin in liposomes: pharmacological, toxicological and therapeutic evaluation.
por: Gokhale, P. C., et al.
Publicado: (1996)

Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide)
por: Skalickova, Sylvie, et al.
Publicado: (2016)

Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity
por: Soler-Agesta, Ruth, et al.
Publicado: (2022)

Pegylated liposomal-encapsulated doxorubicin in cutaneous composite lymphoma: A case report
por: Wollina, Uwe, et al.
Publicado: (2016)

Engineering of Doxorubicin-Encapsulating and TRAIL-Conjugated Poly(RGD) Proteinoid Nanocapsules for Drug Delivery Applications
por: Hadad, Elad, et al.
Publicado: (2020)

Preparation of a PEGylated liposome that co-encapsulates l-arginine and doxorubicin to achieve a synergistic anticancer effect
por: Feng, Haitao, et al.
Publicado: (2021)

Targeting doxorubicin encapsulated in stealth liposomes to solid tumors by non thermal diode laser
por: Ghannam, Magdy M., et al.
Publicado: (2016)

Liposome encapsulation of doxorubicin and celecoxib in combination inhibits progression of human skin cancer cells
por: Singh, Sanjay
Publicado: (2018)

Local Targeted Therapy of Liver Metastasis from Colon Cancer by Galactosylated Liposome Encapsulated with Doxorubicin
por: Zhao, Chen, et al.
Publicado: (2013)

Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review
por: Ibrahim, Mihad, et al.
Publicado: (2022)

Harnessing Nanomedicine to Potentiate the Chemo-Immunotherapeutic Effects of Doxorubicin and Alendronate Co-Encapsulated in Pegylated Liposomes
por: Gabizon, Alberto, et al.
Publicado: (2023)

Exploiting extraordinary topological optical forces at bound states in the continuum
por: Qin, Haoye, et al.
Publicado: (2022)

Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells
por: Rambow, Anna-Christina, et al.
Publicado: (2022)

Tuftsin-Bearing Liposomes Co-Encapsulated with Doxorubicin and Curcumin Efficiently Inhibit EAC Tumor Growth in Mice
por: Murugesan, Kalaimathi, et al.
Publicado: (2020)

Preparation and Evaluation of Thermosensitive Liposomes Encapsulating I-125-Labeled Doxorubicin Derivatives for Auger Electron Therapy
por: Elghobary, Mohamed Elsaid Nasr, et al.
Publicado: (2023)

Preparation, Characterization, and in Vitro/in Vivo Evaluation of Paclitaxel-Bound Albumin-Encapsulated Liposomes for the Treatment of Pancreatic Cancer
por: Okamoto, Yuko, et al.
Publicado: (2019)

Tumor-homing bacterium-adsorbed liposomes encapsulating perfluorohexane/doxorubicin enhance pulsed-focused ultrasound for tumor therapy
por: Ou, Xia, et al.
Publicado: (2023)

The Incorporation of Carvacrol into Poly (vinyl alcohol) Films Encapsulated in Lecithin Liposomes
por: Andrade, Johana, et al.
Publicado: (2020)

Liposomal Encapsulation of Carvacrol to Obtain Active Poly (Vinyl Alcohol) Films
por: Andrade, Johana, et al.
Publicado: (2021)

Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes
por: Kamezaki, Chihiro, et al.
Publicado: (2016)

Synergistic antitumor effects of circularly permuted TRAIL with doxorubicin in triple-negative breast cancer: Circularly permuted TRAIL with Dox in TNBC
por: Liu, Jia, et al.
Publicado: (2023)

Hemihypoatrophy as an extraordinary manifestation of linear morphoea
por: Mansilla-Polo, Miguel, et al.
Publicado: (2022)

Development of antiproliferative long-circulating liposomes co-encapsulating doxorubicin and curcumin, through the use of a quality-by-design approach
por: Tefas, Lucia Ruxandra, et al.
Publicado: (2017)

Co-Encapsulation of Simvastatin and Doxorubicin into pH-Sensitive Liposomes Enhances Antitumoral Activity in Breast Cancer Cell Lines
por: Duarte, Jaqueline Aparecida, et al.
Publicado: (2023)

Leading at the edge: Leadership lessons from the extraordinary saga of Shackleton's antarctic expedition
por: Perkins, Dennis N T, et al.
Publicado: (2000)

Mechanism of retraction of the trailing edge during fibroblast movement
Publicado: (1981)

Pegylated liposomal doxorubicin in ovarian cancer
por: Green, Andrew E, et al.
Publicado: (2006)

Pegylated liposomal doxorubicin in ovarian cancer
por: Strother, Robert, et al.
Publicado: (2009)

Pegylated liposomal doxorubicin for myeloid neoplasms
por: Zhang, Cheng, et al.
Publicado: (2019)

The Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
por: Parajuli, Bidur, et al.
Publicado: (2013)

An Extraordinary Issue for Extraordinary Times
por: Sammons, Morgan T.
Publicado: (2020)

Mesoscopic Modeling of the Encapsulation of Capsaicin by Lecithin/Chitosan Liposomal Nanoparticles
por: Terrón-Mejía, Ketzasmin A., et al.
Publicado: (2018)

Targeting Glioblastoma Cells Expressing CD44 with Liposomes Encapsulating Doxorubicin and Displaying Chlorotoxin-IgG Fc Fusion Protein
por: Mahmud, Hafizah, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rt696g1e3nqk38otd37d3ah5im