Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features

Components of the pre-messenger RNA splicing machinery are frequently mutated in myeloid malignancies. Mutations in LUC7L2, PRPF8, SF3B1, SRSF2, U2AF1, and ZRSR2 genes occur at various frequencies ranging between 40% and 85% in different subtypes of myelodysplastic syndrome (MDS) and 5% and 10% of a...

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Detalles Bibliográficos
Autores principales: Visconte, Valeria, O. Nakashima, Megan, J. Rogers, Heesun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966670/
https://www.ncbi.nlm.nih.gov/pubmed/31766606
http://dx.doi.org/10.3390/cancers11121844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966670/
https://www.ncbi.nlm.nih.gov/pubmed/31766606
http://dx.doi.org/10.3390/cancers11121844

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