Cargando…

Gigantol Targets Cancer Stem Cells and Destabilizes Tumors via the Suppression of the PI3K/AKT and JAK/STAT Pathways in Ectopic Lung Cancer Xenografts

Lung cancer has long been recognized as an important world heath concern due to its high incidence and death rate. The failure of treatment strategies, as well as the regrowth of the disease driven by cancer stem cells (CSCs) residing in the tumor, lead to the urgent need for a novel CSC-targeting t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Losuwannarak, Nattanan, Maiuthed, Arnatchai, Kitkumthorn, Nakarin, Leelahavanichkul, Asada, Roytrakul, Sittiruk, Chanvorachote, Pithi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966687/ https://www.ncbi.nlm.nih.gov/pubmed/31861050 http://dx.doi.org/10.3390/cancers11122032

Ejemplares similares

Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells
por: Bhummaphan, Narumol, et al.
Publicado: (2015)

Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells
por: Unahabhokha, Thitita, et al.
Publicado: (2016)

Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound
por: Tungsukruthai, Sucharat, et al.
Publicado: (2021)

Recycled Sericin Hydrolysates Modified by Alcalase(®) Suppress Melanogenesis in Human Melanin-Producing Cells via Modulating MITF
por: Joyjamras, Keerati, et al.
Publicado: (2022)

Chitooligosaccharide from Pacific White Shrimp Shell Chitosan Ameliorates Inflammation and Oxidative Stress via NF-κB, Erk1/2, Akt and Nrf2/HO-1 Pathways in LPS-Induced RAW264.7 Macrophage Cells
por: Chotphruethipong, Lalita, et al.
Publicado: (2023)

Hydroquinone 5-O-Cinnamoyl Ester of Renieramycin M Suppresses Lung Cancer Stem Cells by Targeting Akt and Destabilizes c-Myc
por: Hongwiangchan, Nattamon, et al.
Publicado: (2021)

Chemosensitizing activity of peptide from Lentinus squarrosulus (Mont.) on cisplatin-induced apoptosis in human lung cancer cells
por: Khine, Hnin Ei Ei, et al.
Publicado: (2021)

Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2
por: Maiuthed, Arnatchai, et al.
Publicado: (2018)

Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction
por: Wattanathamsan, Onsurang, et al.
Publicado: (2023)

Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells
por: Yu, Shubin, et al.
Publicado: (2018)

Gigantol Attenuates the Metastasis of Human Bladder Cancer Cells, Possibly Through Wnt/EMT Signaling
por: Zhao, Meili, et al.
Publicado: (2020)

Extraction and Analysis of Gigantol from Dendrobium officinale with Response Surface Methodology
por: Zheng, Siyan, et al.
Publicado: (2018)

Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications
por: Kitkumthorn, Nakarin, et al.
Publicado: (2011)

Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs
por: Boonyarattanasoonthorn, Tussapon, et al.
Publicado: (2022)

Garcinia mangostana L. Pericarp Extract and Its Active Compound α-Mangostin as Potential Inhibitors of Immune Checkpoint Programmed Death Ligand-1
por: Naing, Sandar, et al.
Publicado: (2023)

Gigantol inhibits cell proliferation and induces apoptosis by regulating DEK in non-small cell lung cancer
por: Cai, Yuxing, et al.
Publicado: (2021)

Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells
por: Basque, Audrey, et al.
Publicado: (2021)

Caveolin-1 Regulates Endothelial Adhesion of Lung Cancer Cells via Reactive Oxygen Species-Dependent Mechanism
por: Chanvorachote, Pithi, et al.
Publicado: (2013)

Ectopic A-lattice seams destabilize microtubules
por: Katsuki, Miho, et al.
Publicado: (2014)

Ouabain Suppresses the Migratory Behavior of Lung Cancer Cells
por: Pongrakhananon, Varisa, et al.
Publicado: (2013)

Synthesis and Biological Evaluation of Novel Gigantol Derivatives as Potential Agents in Prevention of Diabetic Cataract
por: Wu, Jie, et al.
Publicado: (2015)

Triclosan Potentiates Epithelial-To-Mesenchymal Transition in Anoikis-Resistant Human Lung Cancer Cells
por: Winitthana, Thidarat, et al.
Publicado: (2014)

Epithelial-mesenchymal transition mediates anoikis resistance and enhances invasion in pleural effusion-derived human lung cancer cells
por: CHUNHACHA, PREEDAKORN, et al.
Publicado: (2013)

Cycloartocarpin Inhibits Migration through the Suppression of Epithelial-to-Mesenchymal Transition and FAK/AKT Signaling in Non-Small-Cell Lung Cancer Cells
por: Tungsukruthai, Sucharat, et al.
Publicado: (2022)

280. A cross-sectional pilot study on the relationship of gut microbiota pattern to immunogenicity of influenza vaccine in lupus patients
por: Kiewsanuan, Nathathai, et al.
Publicado: (2023)

Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3
por: Petpiroon, Nareerat, et al.
Publicado: (2017)

6,6′-((Methylazanedyl)bis(methylene))bis(2,4-dimethylphenol) Induces Autophagic Associated Cell Death through mTOR-Mediated Autophagy in Lung Cancer
por: Sriratanasak, Nicharat, et al.
Publicado: (2022)

Correction: Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3
por: Petpiroon, Nareerat, et al.
Publicado: (2023)

Long-Term Nitric Oxide Exposure Enhances Lung Cancer Cell Migration
por: Sanuphan, Arpasinee, et al.
Publicado: (2013)

Zinc induces epithelial to mesenchymal transition in human lung cancer H460 cells via superoxide anion-dependent mechanism
por: Ninsontia, Chuanpit, et al.
Publicado: (2016)

Corrigendum to “Long-Term Nitric Oxide Exposure Enhances Lung Cancer Cell Migration”
por: Sanuphan, Arpasinee, et al.
Publicado: (2015)

Moscatilin Inhibits Lung Cancer Cell Motility and Invasion via Suppression of Endogenous Reactive Oxygen Species
por: Kowitdamrong, Akkarawut, et al.
Publicado: (2013)

Ovalitenone Inhibits the Migration of Lung Cancer Cells via the Suppression of AKT/mTOR and Epithelial-to-Mesenchymal Transition
por: Sanookpan, Kittipong, et al.
Publicado: (2021)

Cisplatin-induced hydroxyl radicals mediate pro-survival autophagy in human lung cancer H460 cells
por: Sumkhemthong, Somruethai, et al.
Publicado: (2021)

Cypripedin diminishes an epithelial-to-mesenchymal transition in non-small cell lung cancer cells through suppression of Akt/GSK-3β signalling
por: Treesuwan, Surassawadee, et al.
Publicado: (2018)

Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism
por: Sriratanasak, Nicharat, et al.
Publicado: (2022)

Peptides extracted from edible mushroom: Lentinus squarrosulus induces apoptosis in human lung cancer cells
por: Prateep, Arisara, et al.
Publicado: (2017)

5-O-Acetyl-Renieramycin T from Blue Sponge Xestospongia sp. Induces Lung Cancer Stem Cell Apoptosis
por: Chantarawong, Wipa, et al.
Publicado: (2019)

Renieramycin T Induces Lung Cancer Cell Apoptosis by Targeting Mcl-1 Degradation: A New Insight in the Mechanism of Action
por: Petsri, Korrakod, et al.
Publicado: (2019)

Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract
por: Wu, Jie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_q3k6pi267o61du297b7qea9g4c