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Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
BACKGROUND: α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallmarks of α-synucleinopathies, such as Parkinson’s disease (PD) or dementia with...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966864/ https://www.ncbi.nlm.nih.gov/pubmed/31988747 http://dx.doi.org/10.1186/s40035-019-0181-9 |