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Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

BACKGROUND: α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallmarks of α-synucleinopathies, such as Parkinson’s disease (PD) or dementia with...

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Detalles Bibliográficos
Autores principales:	Candelise, Niccolo, Schmitz, Matthias, Thüne, Katrin, Cramm, Maria, Rabano, Alberto, Zafar, Saima, Stoops, Erik, Vanderstichele, Hugo, Villar-Pique, Anna, Llorens, Franc, Zerr, Inga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966864/ https://www.ncbi.nlm.nih.gov/pubmed/31988747 http://dx.doi.org/10.1186/s40035-019-0181-9

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