Cargando…

Tizanidine (Hydrochloride) Inhibits A549 Lung Cancer Cell Proliferation and Motility Through Regulating Nischarin

PURPOSE: Tizanidine hydrochloride (TZN) is a centrally acting α(2)-adrenergic agonist. In this study, we aimed to explore the role of TZN on human lung cancer and to elucidate its underlying mechanisms. METHODS: The effect of TZN treatment in A549 cell proliferation, migration, invasion and apoptosi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Liang, Zhao, Gefei, Xue, Qi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966956/ https://www.ncbi.nlm.nih.gov/pubmed/32021275 http://dx.doi.org/10.2147/OTT.S228317

Ejemplares similares

Optimization of Microemulgel for Tizanidine Hydrochloride
por: Jagdale, Swati, et al.
Publicado: (2020)

Isolation and Characterization of a Process Impurity in Tizanidine Hydrochloride
por: Vijayakumar, E. K. S., et al.
Publicado: (2010)

Tizanidine hydrochloride exhibits a cytotoxic effect on osteosarcoma cells through the PI3K/AKT signaling pathway
por: Xing, Xue-Wu, et al.
Publicado: (2019)

Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity
por: Ding, Yuemin, et al.
Publicado: (2015)

Impact of Nischarin on EMT regulators in breast cancer cell lines
por: Cai, Yuan-Jie, et al.
Publicado: (2020)

Nischarin Is Differentially Expressed in Rat Brain and Regulates Neuronal Migration
por: Ding, Yuemin, et al.
Publicado: (2013)

Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells
por: Maziveyi, Mazvita, et al.
Publicado: (2018)

Expression of integrin-binding protein Nischarin in metastatic breast cancer
por: CHEN, JIE, et al.
Publicado: (2015)

Nischarin, a Novel Protein That Interacts with the Integrin α5 Subunit and Inhibits Cell Migration
por: Alahari, Suresh K., et al.
Publicado: (2000)

Nischarin attenuates apoptosis induced by oxidative stress in PC12 cells
por: Guo, Zhanpeng, et al.
Publicado: (2019)

XAV939 inhibits the proliferation and migration of lung adenocarcinoma A549 cells through the WNT pathway
por: Li, Chong, et al.
Publicado: (2018)

Formulation of tizanidine hydrochloride–loaded provesicular system for improved oral delivery and therapeutic activity employing a 2(3) full factorial design
por: Mohsen, Amira Mohamed, et al.
Publicado: (2022)

Management of Tizanidine Withdrawal Syndrome: A Case Report
por: Suárez-Lledó, A, et al.
Publicado: (2018)

Tizanidine Toxicity From Ciprofloxacin: A Cautionary Tale
por: Goyal, Lokesh, et al.
Publicado: (2022)

The non-adrenergic imidazoline-1 receptor protein nischarin is a key regulator of astrocyte glutamate uptake
por: Gupta, Swati, et al.
Publicado: (2022)

Effect of receptor for hyaluronan-mediated motility inhibition on radiosensitivity of lung adenocarcinoma A549 cells
por: Gao, Chunzi, et al.
Publicado: (2019)

Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells
por: Hao, Wenhui, et al.
Publicado: (2014)

Pediatric tizanidine toxicity reversed with naloxone: a case report
por: Bader, Doaa, et al.
Publicado: (2021)

Pre-emptive tizanidine as an opioid-sparing medication in elective surgeries
por: Nair, Abhijit
Publicado: (2023)

SPAG5 is associated with unfavorable prognosis in patients with lung adenocarcinoma and promotes proliferation, motility and autophagy in A549 cells
por: Huang, Ruijia, et al.
Publicado: (2020)

Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway
por: Pei, Wanmin, et al.
Publicado: (2018)

Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer
por: Eastlack, Steven C., et al.
Publicado: (2018)

Luteolin inhibits A549 cells proliferation and migration by down-regulating androgen receptors
por: Li, Xu, et al.
Publicado: (2023)

Tizanidine-induced acute severe cystitis in a female taking famotidine
por: Poudel, Resham Raj, et al.
Publicado: (2015)

Potassium wasting nephropathy in the setting of tizanidine overdose: a case report
por: Brucculeri, Michael J., et al.
Publicado: (2021)

Coadministration of tizanidine and ciprofloxacin: a retrospective analysis of the WHO pharmacovigilance database
por: Rudolph, Annette, et al.
Publicado: (2021)

A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways
por: Crompton, Michael, et al.
Publicado: (2017)

Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor
por: Bennett, Dominic F., et al.
Publicado: (2023)

Comparing the efficacy of botulinum toxin with tizanidine in upper limb post stroke spasticity
por: Yazdchi, Mohammad, et al.
Publicado: (2013)

The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy
por: Talakoub, Reihanak, et al.
Publicado: (2016)

Spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test
por: Ouyang, Handong, et al.
Publicado: (2015)

The mechanism of trans-δ-viniferin inhibiting the proliferation of lung cancer cells A549 by targeting the mitochondria
por: Yin, Ruochun, et al.
Publicado: (2023)

Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro
por: JIANG, HONG-FANG, et al.
Publicado: (2014)

Effects of maslinic acid on the proliferation and apoptosis of A549 lung cancer cells
por: BAI, XUE, et al.
Publicado: (2016)

βcaryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
por: Shabana, Sameh M., et al.
Publicado: (2023)

Ambroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells
por: Md, Shadab, et al.
Publicado: (2021)

Development of Orodispersible Tizanidine HCl Tablets Using Spray Dried Coprocessed Exipient Bases
por: Masareddy, Rajashree, et al.
Publicado: (2011)

Corrigendum to “Spinal Antinociceptive Action of Amiloride and Its Interaction with Tizanidine in the Rat Formalin Test”
por: Ouyang, Handong, et al.
Publicado: (2016)

Development of Tizanidine HCl-Meloxicam loaded mucoadhesive buccal films: In-vitro and in-vivo evaluation
por: Zaman, Muhammad, et al.
Publicado: (2018)

Effect of Sevoflurane on the Proliferation of A549 Lung Cancer Cells
por: Yun, Sangwon, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_eoejlj0va3e50q647bkmga1ani