TLR7 Agonism Accelerates Disease and Causes a Fatal Myeloproliferative Disorder in NZM 2410 Lupus Mice

Murine models of lupus, both spontaneous and inducible, are valuable instruments to study SLE pathogenesis. Accelerants such as Type I IFN are often used to trigger earlier disease onset. We used a topical TLR7 agonist, previously reported to induce lupus-like disease in WT mice within weeks, to val...

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Detalles Bibliográficos
Autores principales: Wirth, Jena R., Molano, Ivan, Ruiz, Phil, Coutermarsh-Ott, Sheryl, Cunningham, Melissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967132/
https://www.ncbi.nlm.nih.gov/pubmed/31998321
http://dx.doi.org/10.3389/fimmu.2019.03054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967132/
https://www.ncbi.nlm.nih.gov/pubmed/31998321
http://dx.doi.org/10.3389/fimmu.2019.03054

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