Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) inhibition, when the majority of novel compounds...

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Detalles Bibliográficos
Autores principales: Malinak, David, Dolezal, Rafael, Hepnarova, Vendula, Hozova, Miroslava, Andrys, Rudolf, Bzonek, Petr, Racakova, Veronika, Korabecny, Jan, Gorecki, Lukas, Mezeiova, Eva, Psotka, Miroslav, Jun, Daniel, Kuca, Kamil, Musilek, Kamil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968506/
https://www.ncbi.nlm.nih.gov/pubmed/31910701
http://dx.doi.org/10.1080/14756366.2019.1710501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968506/
https://www.ncbi.nlm.nih.gov/pubmed/31910701
http://dx.doi.org/10.1080/14756366.2019.1710501

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