Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3

3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives were designed and synthesised as selective inhibitors of JNK3, a target for the treatment of neurodegenerative diseases. Following previous studies, we have designed JNK3 inhibitors to reduce the molecular weight and successfully identified a lead c...

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Detalles Bibliográficos
Autores principales: Oh, Youri, Jang, Miyoung, Cho, Hyunwook, Yang, Songyi, Im, Daseul, Moon, Hyungwoo, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968587/
https://www.ncbi.nlm.nih.gov/pubmed/31856610
http://dx.doi.org/10.1080/14756366.2019.1705294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968587/
https://www.ncbi.nlm.nih.gov/pubmed/31856610
http://dx.doi.org/10.1080/14756366.2019.1705294

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