Assessment of contribution of BCRP to intestinal absorption of various drugs using portal‐systemic blood concentration difference model in mice

Prediction of the intestinal absorption of new chemical entities (NCEs) is still difficult, in part because drug efflux transporters, including breast cancer resistance protein (BCRP) and P‐glycoprotein (P‐gp), restrict their intestinal permeability. We have demonstrated that the absorptive quotient...

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Detalles Bibliográficos
Autores principales: Kawahara, Iichiro, Nishikawa, Satoyo, Yamamoto, Akira, Kono, Yusuke, Fujita, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968775/
https://www.ncbi.nlm.nih.gov/pubmed/31988753
http://dx.doi.org/10.1002/prp2.544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968775/
https://www.ncbi.nlm.nih.gov/pubmed/31988753
http://dx.doi.org/10.1002/prp2.544

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