β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

Glycosylation is critical to megakaryocyte (MK) and thrombopoiesis in the context of gene mutations that affect sialylation and galactosylation. Here, we identify the conserved B4galt1 gene as a critical regulator of thrombopoiesis in MKs. β4GalT1 deficiency increases the number of fully differentia...

Descripción completa

Detalles Bibliográficos
Autores principales: Giannini, Silvia, Lee-Sundlov, Melissa M., Rivadeneyra, Leonardo, Di Buduo, Christian A., Burns, Robert, Lau, Joseph T., Falet, Hervé, Balduini, Alessandra, Hoffmeister, Karin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968998/
https://www.ncbi.nlm.nih.gov/pubmed/31953383
http://dx.doi.org/10.1038/s41467-019-14178-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968998/
https://www.ncbi.nlm.nih.gov/pubmed/31953383
http://dx.doi.org/10.1038/s41467-019-14178-y

Ejemplares similares