A robust and efficient method for Mendelian randomization with hundreds of genetic variants

Mendelian randomization (MR) is an epidemiological technique that uses genetic variants to distinguish correlation from causation in observational data. The reliability of a MR investigation depends on the validity of the genetic variants as instrumental variables (IVs). We develop the contamination...

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Detalles Bibliográficos
Autores principales: Burgess, Stephen, Foley, Christopher N, Allara, Elias, Staley, James R, Howson, Joanna M. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969055/
https://www.ncbi.nlm.nih.gov/pubmed/31953392
http://dx.doi.org/10.1038/s41467-019-14156-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969055/
https://www.ncbi.nlm.nih.gov/pubmed/31953392
http://dx.doi.org/10.1038/s41467-019-14156-4

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