Cargando…

Reduced Expression of Genes Regulating Cohesion Induces Chromosome Instability that May Promote Cancer and Impact Patient Outcomes

Chromosome instability (CIN), or continual changes in chromosome complements, is an enabling feature of cancer; however, the molecular determinants of CIN remain largely unknown. Emerging data now suggest that aberrant sister chromatid cohesion may induce CIN and contribute to cancer. To explore thi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leylek, Tarik R., Jeusset, Lucile M., Lichtensztejn, Zelda, McManus, Kirk J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969069/ https://www.ncbi.nlm.nih.gov/pubmed/31953484 http://dx.doi.org/10.1038/s41598-020-57530-9

Ejemplares similares

Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis
por: Baergen, Allison K., et al.
Publicado: (2019)

Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis
por: Jeusset, Lucile M., et al.
Publicado: (2021)

Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells
por: Sajesh, Babu V, et al.
Publicado: (2013)

Reduced SKP1 Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover
por: Thompson, Laura L., et al.
Publicado: (2020)

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer
por: Thompson, Laura L., et al.
Publicado: (2017)

The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples
por: Penner-Goeke, Signe, et al.
Publicado: (2017)

Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells
por: Neudorf, Nicole M., et al.
Publicado: (2022)

Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer
por: Lepage, Chloe Camille, et al.
Publicado: (2021)

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer
por: Jeusset, Lucile M-P., et al.
Publicado: (2017)

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
por: Jeusset, Lucile M-P, et al.
Publicado: (2019)

The F-box protein, FBXO7, is required to maintain chromosome stability in humans
por: Palmer, Michaela C L, et al.
Publicado: (2021)

Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes
por: Vishwakarma, Raghvendra, et al.
Publicado: (2020)

Characterizing the Prevalence of Chromosome Instability in Interval Colorectal Cancer()()
por: Cisyk, A.L., et al.
Publicado: (2015)

Synthetic Lethal Targeting of Superoxide Dismutase 1 Selectively Kills RAD54B-Deficient Colorectal Cancer Cells
por: Sajesh, Babu V., et al.
Publicado: (2013)

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers
por: Cisyk, Amy L., et al.
Publicado: (2018)

A Novel Multiplexed, Image-Based Approach to Detect Phenotypes That Underlie Chromosome Instability in Human Cells
por: Thompson, Laura L., et al.
Publicado: (2015)

Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity
por: Lepage, Chloe C., et al.
Publicado: (2019)

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability
por: Lepage, Chloe C., et al.
Publicado: (2020)

BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
por: Brownlee, Peter M., et al.
Publicado: (2014)

Aberrant HMGA2 Expression Sustains Genome Instability That Promotes Metastasis and Therapeutic Resistance in Colorectal Cancer
por: Campos Gudiño, Rubi, et al.
Publicado: (2023)

Synthetic Genetic Targeting of Genome Instability in Cancer
por: Sajesh, Babu V., et al.
Publicado: (2013)

Aberrant SKP1 Expression: Diverse Mechanisms Impacting Genome and Chromosome Stability
por: Thompson, Laura L., et al.
Publicado: (2022)

Impact of chromosomal instability on colorectal cancer progression and outcome
por: Orsetti, Béatrice, et al.
Publicado: (2014)

The DNA-binding protein CST associates with the cohesin complex and promotes chromosome cohesion
por: Schuck, P. Logan, et al.
Publicado: (2021)

Loss of ATRX leads to chromosome cohesion and congression defects
por: Ritchie, Kieran, et al.
Publicado: (2008)

Transcription facilitates sister chromatid cohesion on chromosomal arms
por: Bhardwaj, Shweta, et al.
Publicado: (2016)

3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps"
por: Knecht, Hans, et al.
Publicado: (2010)

Neuroblastoma Patients’ Outcome and Chromosomal Instability
por: Ognibene, Marzia, et al.
Publicado: (2023)

The SCF Complex Is Essential to Maintain Genome and Chromosome Stability
por: Thompson, Laura L., et al.
Publicado: (2021)

Chromosome Cohesion: A Cycle of Holding Together and Falling Apart
por: Gerton, Jennifer
Publicado: (2005)

Cohesive and Non-Cohesive Gold
por: Rice, J. S.
Publicado: (1875)

Cohesion promotes nucleolar structure and function
por: Harris, Bethany, et al.
Publicado: (2014)

Whole Chromosome Instability induces senescence and promotes SASP
por: Andriani, Grasiella Angelina, et al.
Publicado: (2016)

PRL-3 promotes telomere deprotection and chromosomal instability
por: Lian, Shenyi, et al.
Publicado: (2017)

TNFα promoter single nucleotide polymorphisms may influence gene expression in patients with severe sepsis
por: Odwyer, M, et al.
Publicado: (2007)

Chromosome Segregation in Budding Yeast: Sister Chromatid Cohesion and Related Mechanisms
por: Marston, Adele L.
Publicado: (2014)

Nucleosome Assembly Proteins Get SET to Defeat the Guardian of Chromosome Cohesion
por: Higgins, Jonathan M. G., et al.
Publicado: (2013)

Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2
por: McNicoll, François, et al.
Publicado: (2020)

Cohesive and Non Cohesive Golds—Correspondence
Publicado: (1881)

Pds5p regulates the maintenance of sister chromatid cohesion and is sumoylated to promote the dissolution of cohesion
por: Stead, Kristen, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_ps581ojnl9v417bgk8rjhqn3sn