Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains

Early in vivo studies demonstrated the involvement of a tumor-suppressing transcription factor, p53, into cellular droplets such as Cajal and promyelocytic leukemia protein bodies, suggesting that the liquid-liquid phase separation (LLPS) might be involved in the cellular functions of p53. To examin...

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Detalles Bibliográficos
Autores principales: Kamagata, Kiyoto, Kanbayashi, Saori, Honda, Masaya, Itoh, Yuji, Takahashi, Hiroto, Kameda, Tomoshi, Nagatsugi, Fumi, Takahashi, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969132/
https://www.ncbi.nlm.nih.gov/pubmed/31953488
http://dx.doi.org/10.1038/s41598-020-57521-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969132/
https://www.ncbi.nlm.nih.gov/pubmed/31953488
http://dx.doi.org/10.1038/s41598-020-57521-w

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