Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

The extent to which the impact of regulatory genetic variants may depend on other factors, such as the expression levels of upstream transcription factors, remains poorly understood. Here we report a framework in which regulatory variants are first aggregated into sets, and using these as estimates...

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Detalles Bibliográficos
Autores principales: Wragg, D., Liu, Q., Lin, Z., Riggio, V., Pugh, C. A., Beveridge, A. J., Brown, H., Hume, D. A., Harris, S. E., Deary, I. J., Tenesa, A., Prendergast, J. G. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969137/
https://www.ncbi.nlm.nih.gov/pubmed/31953380
http://dx.doi.org/10.1038/s41467-019-13762-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969137/
https://www.ncbi.nlm.nih.gov/pubmed/31953380
http://dx.doi.org/10.1038/s41467-019-13762-6

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