Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape

Vaccination has essentially eradicated poliovirus. Yet, its mutation rate is higher than that of viruses like HIV, for which no effective vaccine exists. To investigate this, we infer a fitness model for the poliovirus viral protein 1 (vp1), which successfully predicts in vitro fitness measurements....

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Detalles Bibliográficos
Autores principales: Quadeer, Ahmed A., Barton, John P., Chakraborty, Arup K., McKay, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969152/
https://www.ncbi.nlm.nih.gov/pubmed/31953427
http://dx.doi.org/10.1038/s41467-019-14174-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969152/
https://www.ncbi.nlm.nih.gov/pubmed/31953427
http://dx.doi.org/10.1038/s41467-019-14174-2

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