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Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
Vaccination has essentially eradicated poliovirus. Yet, its mutation rate is higher than that of viruses like HIV, for which no effective vaccine exists. To investigate this, we infer a fitness model for the poliovirus viral protein 1 (vp1), which successfully predicts in vitro fitness measurements....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969152/ https://www.ncbi.nlm.nih.gov/pubmed/31953427 http://dx.doi.org/10.1038/s41467-019-14174-2 |