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Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge

The human Mre11/Rad50 complex is one of the key factors in genome maintenance pathways. Previous nanoscale imaging by atomic force microscopy (AFM) showed that the ring-like structure of the human Mre11/Rad50 complex transiently opens at the zinc hook of Rad50. However, imaging of the human Mre11/Ra...

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Detalles Bibliográficos
Autores principales: Tatebe, Hisashi, Lim, Chew Theng, Konno, Hiroki, Shiozaki, Kazuhiro, Shinohara, Akira, Uchihashi, Takayuki, Furukohri, Asako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969161/
https://www.ncbi.nlm.nih.gov/pubmed/31953386
http://dx.doi.org/10.1038/s41467-019-14025-0