The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

Pyrazinamide has been a mainstay in the multidrug regimens used to treat tuberculosis. It is active against the persistent, non-replicating mycobacteria responsible for the protracted therapy required to cure tuberculosis. Pyrazinamide is a pro-drug that is converted into pyrazinoic acid (POA) by py...

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Detalles Bibliográficos
Autores principales: Sun, Qingan, Li, Xiaojun, Perez, Lisa M., Shi, Wanliang, Zhang, Ying, Sacchettini, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969166/
https://www.ncbi.nlm.nih.gov/pubmed/31953389
http://dx.doi.org/10.1038/s41467-019-14238-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969166/
https://www.ncbi.nlm.nih.gov/pubmed/31953389
http://dx.doi.org/10.1038/s41467-019-14238-3

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