De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance

BACKGROUND: STAT5 plays an important role in the transformation of hematopoietic cells by BCR-ABL. However, the downstream target genes activated by STAT5 in chronic myeloid leukemia (CML) cells remain largely unclear. Here, we investigated the mechanistic functional relationship between STAT5A-regu...

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Detalles Bibliográficos
Autores principales: Nie, Zi-Yuan, Yao, Min, Yang, Zhan, Yang, Lin, Liu, Xiao-Jun, Yu, Jing, Ma, Ying, Zhang, Nan, Zhang, Xiao-Yan, Liu, Meng-Han, Jiang, Ling-Ling, Luo, Jian-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969434/
https://www.ncbi.nlm.nih.gov/pubmed/31952546
http://dx.doi.org/10.1186/s13046-019-1502-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969434/
https://www.ncbi.nlm.nih.gov/pubmed/31952546
http://dx.doi.org/10.1186/s13046-019-1502-7

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