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Proteome-wide observation of the phenomenon of life on the edge of solubility
To function effectively proteins must avoid aberrant aggregation, and hence they are expected to be expressed at concentrations safely below their solubility limits. By analyzing proteome-wide mass spectrometry data of Caenorhabditis elegans, however, we show that the levels of about three-quarters...
Autores principales: | Vecchi, Giulia, Sormanni, Pietro, Mannini, Benedetta, Vandelli, Andrea, Tartaglia, Gian Gaetano, Dobson, Christopher M., Hartl, F. Ulrich, Vendruscolo, Michele |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969518/ https://www.ncbi.nlm.nih.gov/pubmed/31892536 http://dx.doi.org/10.1073/pnas.1910444117 |
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