PET imaging of mGluR5 in Alzheimer’s disease

BACKGROUND: Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We utilized the positron emission tomography (PET) radioligand [(...

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Detalles Bibliográficos
Autores principales: Mecca, Adam P., McDonald, Julia W., Michalak, Hannah R., Godek, Tyler A., Harris, Joanna E., Pugh, Erika A., Kemp, Emily C., Chen, Ming-Kai, Salardini, Arash, Nabulsi, Nabeel B., Lim, Keunpoong, Huang, Yiyun, Carson, Richard E., Strittmatter, Stephen M., van Dyck, Christopher H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969979/
https://www.ncbi.nlm.nih.gov/pubmed/31954399
http://dx.doi.org/10.1186/s13195-020-0582-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969979/
https://www.ncbi.nlm.nih.gov/pubmed/31954399
http://dx.doi.org/10.1186/s13195-020-0582-0

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