Synthetic Evidence of the Amadori-Type Alkylation of Biogenic Amines by the Neurotoxic Metabolite Dopegal

[Image: see text] The neurotransmitter metabolite 3,4-dihydroxy-phenylglycolaldehyde (dopegal) damages neurons and the myocardium by protein cross-linking, resulting in conglomerations and cell death. We investigated this process on a synthetic scale, leading to the discovery of an Amadori-type rear...

Descripción completa

Detalles Bibliográficos
Autores principales: Wanner, Martin J., Zuidinga, Ed, Tromp, Dorette S., Vilím, Jan, Jørgensen, Steen Ingemann, van Maarseveen, Jan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970265/
https://www.ncbi.nlm.nih.gov/pubmed/31841007
http://dx.doi.org/10.1021/acs.joc.9b01948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970265/
https://www.ncbi.nlm.nih.gov/pubmed/31841007
http://dx.doi.org/10.1021/acs.joc.9b01948

Ejemplares similares