Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation

[Image: see text] PHF8 (KDM7B) is a human non-heme 2-oxoglutarate (2OG) JmjC domain oxygenase that catalyzes the demethylation of the di/mono-N(ε)-methylated K9 residue of histone H3. Altered PHF8 activity is linked to genetic diseases and cancer; thus, it is an interesting target for epigenetic mod...

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Detalles Bibliográficos
Autores principales: Chaturvedi, Shobhit S., Ramanan, Rajeev, Lehnert, Nicolai, Schofield, Christopher J., Karabencheva-Christova, Tatyana G., Christov, Christo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970271/
https://www.ncbi.nlm.nih.gov/pubmed/31976154
http://dx.doi.org/10.1021/acscatal.9b04907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970271/
https://www.ncbi.nlm.nih.gov/pubmed/31976154
http://dx.doi.org/10.1021/acscatal.9b04907

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