Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme

[Image: see text] Mycobacterium tuberculosis (Mtb) possesses a two-component regulatory system, DosRST, that enables Mtb to sense host immune cues and establish a state of nonreplicating persistence (NRP). NRP bacteria are tolerant to several antimycobacterial drugs in vitro and are thought to play...

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Detalles Bibliográficos
Autores principales: Zheng, Huiqing, Williams, John T., Aleiwi, Bilal, Ellsworth, Edmund, Abramovitch, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970277/
https://www.ncbi.nlm.nih.gov/pubmed/31556993
http://dx.doi.org/10.1021/acschembio.8b00849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970277/
https://www.ncbi.nlm.nih.gov/pubmed/31556993
http://dx.doi.org/10.1021/acschembio.8b00849

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