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Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme

[Image: see text] Mycobacterium tuberculosis (Mtb) possesses a two-component regulatory system, DosRST, that enables Mtb to sense host immune cues and establish a state of nonreplicating persistence (NRP). NRP bacteria are tolerant to several antimycobacterial drugs in vitro and are thought to play...

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Detalles Bibliográficos
Autores principales:	Zheng, Huiqing, Williams, John T., Aleiwi, Bilal, Ellsworth, Edmund, Abramovitch, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970277/ https://www.ncbi.nlm.nih.gov/pubmed/31556993 http://dx.doi.org/10.1021/acschembio.8b00849

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