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Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid
BACKGROUND: The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in vivo gene editing, a principal problem in implementing this new process is delivery of h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970287/ https://www.ncbi.nlm.nih.gov/pubmed/31959180 http://dx.doi.org/10.1186/s12951-019-0564-1 |