Inflammation-Associated Microsatellite Alterations Caused by MSH3 Dysfunction Are Prevalent in Ulcerative Colitis and Increase With Neoplastic Advancement

OBJECTIVES: Inflammation-associated microsatellite alterations (also known as elevated microsatellite alterations at selected tetranucleotide repeats [EMAST]) result from IL-6–induced nuclear-to-cytosolic displacement of the DNA mismatch repair (MMR) protein MSH3, allowing frameshifts of dinucleotid...

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Detalles Bibliográficos
Autores principales: Munakata, Koji, Koi, Minoru, Kitajima, Takahito, Tseng-Rogenski, Stephanie, Uemura, Mamoru, Matsuno, Hiroshi, Kawai, Kenji, Sekido, Yuki, Mizushima, Tsunekazu, Toiyama, Yuji, Yamada, Takuya, Mano, Masayuki, Mita, Eiji, Kusunoki, Masato, Mori, Masaki, Carethers, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970556/
https://www.ncbi.nlm.nih.gov/pubmed/31789935
http://dx.doi.org/10.14309/ctg.0000000000000105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970556/
https://www.ncbi.nlm.nih.gov/pubmed/31789935
http://dx.doi.org/10.14309/ctg.0000000000000105

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