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Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (BBB) to reach the central nervous system (CNS), wh...

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Detalles Bibliográficos
Autores principales: Haghayegh Jahromi, Neda, Marchetti, Luca, Moalli, Federica, Duc, Donovan, Basso, Camilla, Tardent, Heidi, Kaba, Elisa, Deutsch, Urban, Pot, Caroline, Sallusto, Federica, Stein, Jens V., Engelhardt, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970977/
https://www.ncbi.nlm.nih.gov/pubmed/31993059
http://dx.doi.org/10.3389/fimmu.2019.03056