TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice

Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or various endogenous diseases related to bacterial translocation from the gut. Systemic inflammatory responses induced by endotoxemia induce severe involuntary loss of skeletal muscle, termed muscle wasti...

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Detalles Bibliográficos
Autores principales: Ono, Yuko, Maejima, Yuko, Saito, Masafumi, Sakamoto, Kazuho, Horita, Shoichiro, Shimomura, Kenju, Inoue, Shigeaki, Kotani, Joji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970997/
https://www.ncbi.nlm.nih.gov/pubmed/31959927
http://dx.doi.org/10.1038/s41598-020-57714-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970997/
https://www.ncbi.nlm.nih.gov/pubmed/31959927
http://dx.doi.org/10.1038/s41598-020-57714-3

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