NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter

In mammals, autophagosome formation is initiated by ULK1 via the posttranslational modification of this protein. However, the precise role of ULK1 ubiquitination in modulating autophagy is unknown. Here, we show that NEDD4L, an E3 ubiquitin ligase, binds ULK1 in pancreatic cancer cells. ULK1 express...

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Detalles Bibliográficos
Autores principales: Lee, Dong-Eun, Yoo, Ju Eun, Kim, Jiyea, Kim, Seungki, Kim, Sunshin, Lee, Ho, Cheong, Heesun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971022/
https://www.ncbi.nlm.nih.gov/pubmed/31959741
http://dx.doi.org/10.1038/s41419-020-2242-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971022/
https://www.ncbi.nlm.nih.gov/pubmed/31959741
http://dx.doi.org/10.1038/s41419-020-2242-5

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