Chronic PD-1 Checkpoint Blockade Does Not Affect Cognition or Promote Tau Clearance in a Tauopathy Mouse Model

Programmed cell death protein 1 (PD-1) checkpoint blockade with an antibody has been shown to reduce amyloid-β plaques, associated pathologies and cognitive impairment in mouse models. More recently, this approach has shown effectiveness in a tauopathy mouse model to improve cognition and reduce tau...

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Detalles Bibliográficos
Autores principales: Lin, Yan, Rajamohamedsait, Hameetha B., Sandusky-Beltran, Leslie A., Gamallo-Lana, Begona, Mar, Adam, Sigurdsson, Einar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971044/
https://www.ncbi.nlm.nih.gov/pubmed/31992982
http://dx.doi.org/10.3389/fnagi.2019.00377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971044/
https://www.ncbi.nlm.nih.gov/pubmed/31992982
http://dx.doi.org/10.3389/fnagi.2019.00377

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