Dopamine D(3) Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats

Prescription opioids, such as oxycodone, are highly effective analgesics for clinical pain management, but approximately 25% of patients who are prescribed opioids misuse them, and 5%–10% develop an opioid use disorder (OUD). Effective therapies for the prevention and treatment of opioid abuse and a...

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Detalles Bibliográficos
Autores principales: de Guglielmo, Giordano, Kallupi, Marsida, Sedighim, Sharona, Newman, Amy H., George, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Behavioral Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971096/
https://www.ncbi.nlm.nih.gov/pubmed/31992976
http://dx.doi.org/10.3389/fnbeh.2019.00292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971096/
https://www.ncbi.nlm.nih.gov/pubmed/31992976
http://dx.doi.org/10.3389/fnbeh.2019.00292

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