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Revealing factors determining immunodominant responses against dominant epitopes

Upon recognition of peptide-MHC complexes by T cell receptors (TCR), the cognate T cells expand and differentiate into effector T cells to generate protective immunity. Despite the fact that any immune response generates a diverse set of TCR clones against a particular epitope, only a few clones are...

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Detalles Bibliográficos
Autores principales: Ritmahan, Wannisa, Kesmir, Can, Vroomans, Renske M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971151/
https://www.ncbi.nlm.nih.gov/pubmed/31811313
http://dx.doi.org/10.1007/s00251-019-01134-9