Efficient base editing with high precision in rabbits using YFE-BE4max

Cytidine base editors, composed of a cytidine deaminase fused to Cas9 nickase, enable efficient C-to-T conversion in various organisms. However, current base editors suffer from severe trade-off between editing efficiency and precision. Here, based on rationally mutated cytidine deaminase domain, we...

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Detalles Bibliográficos
Autores principales: Liu, Zhiquan, Chen, Siyu, Shan, Huanhuan, Jia, Yingqi, Chen, Mao, Song, Yuning, Lai, Liangxue, Li, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971250/
https://www.ncbi.nlm.nih.gov/pubmed/31959743
http://dx.doi.org/10.1038/s41419-020-2244-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971250/
https://www.ncbi.nlm.nih.gov/pubmed/31959743
http://dx.doi.org/10.1038/s41419-020-2244-3

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