Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity

Dendritic cells (DCs) function is intimately linked to microenvironment and metabolism. Type I interferons (IFNs) condition dendritic cells to respond to weak self-signals, leading to autoimmunity. However, the metabolic adaption in the process is unclear. Here, we identified spermidine as a critica...

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Detalles Bibliográficos
Autores principales: Li, Guanhua, Ding, Huihua, Yu, Xiang, Meng, Yao, Li, Jun, Guo, Qiang, Zhou, Haibo, Shen, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971394/
https://www.ncbi.nlm.nih.gov/pubmed/31962236
http://dx.doi.org/10.1016/j.isci.2019.100807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971394/
https://www.ncbi.nlm.nih.gov/pubmed/31962236
http://dx.doi.org/10.1016/j.isci.2019.100807

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